Synthesis, Kinetics, Reaction Mechanism and Biological Activity Studies of Novel 1, 3-Oxazine Compound

Kosrat N. Kaka

doi:10.21271/ZJPAS.35.5.10

Authors

Kosrat N. Kaka Department of Chemistry, Faculty of Science and Health, Koya University, Koya KOY45, Kurdistan Region – F.R. Iraq

DOI:

https://doi.org/10.21271/ZJPAS.35.5.10

Keywords:

Schiff base, Chalcone, Biological Activity, Kinetics, Oxazine

Abstract

A novel 1, 3-Oxazine compound ((E)-8-benzylidene-2-(4-methoxyphenyl)-3,4-diphenyl -3,4,5,6,7,8-hexahydro-2H-benzo[e][1,3]oxazine) was synthesized by reaction of N-(4-methoxybenzylidene)aniline(Schiff base) with 2,6-di((E)-benzylidene)cyclohexan-1-one(chalcone). The structure of 1, 3-Oxazine compound was characterized through spectral data (FT-IR, 1H- NMR and Ultraviolet-Visible spectrophotometer). The kinetics study of the novel synthesized 1, 3-Oxazine compound was studied to determine the order of the reaction and the mechanism pathway. It was found that the reaction is first order undergoes via (imino-Diels-Alder). The reaction rate, Arrhenius factor (A), thermodynamic functions (E_a (free energy of activation), DS^#(entropy of activation), and DG^# (Gibbs energy of activation)) were also calculated and confirmed the formation of 1, 3-Oxazine cycle. Finally, the antibacterial activities against gram negative (Escherichia coli) with gram positive (Staphylococcus aureus) were evaluated optical density for finding minimum inhibition concentration (MIC).

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