Synthesis, biological and antioxidant activity of new diamides derived from sulfonamide drug and local anesthesia

Rebaz Jawhar Qadr; Lana H. Chawshli

doi:10.21271/ZJPAS.35.4.21

Authors

Rebaz Jawhar Qadr Department of Chemistry- College of Education- Salahaddin University-Erbil, Erbil, Kurdistan Region, Iraq
Lana H. Chawshli Department of Chemistry- College of Education- Salahaddin University-Erbil, Erbil, Kurdistan Region, Iraq

DOI:

https://doi.org/10.21271/ZJPAS.35.4.21

Keywords:

Synthesis, diamide, sulfonamide drugs, local anesthesia, biological and antioxidant activity

Abstract

A new series of sulfa drug diamides and local anesthesia diamides (2a-f) and (3a-f) have been prepared through the nucleophilic acyl substitution reaction. The pharmacological profile of all newly synthesized compounds was evaluated in vitro for their antibacterial and antifungal activities using the micro broth dilution assay method and antioxidant activity by the DPPH-radical scavenging method. It was revealed that synthesized compounds were exhibiting promising radical scavenging activity and pharmacological activities against both strains. The structures of synthesized diamides were expounded and elucidated on the bases of their FT-IR, ¹H- and ¹³C –NMR spectral data.

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