One pot and stepwise synthesis of some new azo thiazolidin-4-one derivatives and their biological evaluations.

Chinar M. Burhan; Awaz J. Hussein

doi:10.21271/ZJPAS.35.1.16

Authors

Chinar M. Burhan 1Department of Chemistry, College of Education, Salahaddin University–Erbil, Erbil-Kurdistan, Iraq
Awaz J. Hussein Department of Chemistry, College of Education, Salahaddin University–Erbil, Erbil-Kurdistan, Iraq

DOI:

https://doi.org/10.21271/ZJPAS.35.1.16

Keywords:

Heterocyclic compound, Schiff base, thiazolidinone, mercapto acetic acid, biological activity.

Abstract

(2-(2-(benzyloxy)-5-((4-(6-methylbenzo[d]thiazol-2-yl)phenyl)diazenyl)phenyl)-3- substitutedphenylthiazolidin-4-ones derivatives (4a-h) have been synthesized from the reaction of 2-(benzyloxy)-5-((4-(6-methylbenzo[d]thiazol-2-yl) phenyl)diazenyl)benzaldehyde (2) with different substituted aniline, followed by cyclization with mercaptoacetic acid via either a one-pot three-component condensation and stepwise process. The structure of synthesized compounds were elucidated by FT-IR, ¹H-NMR, ¹³C-NMR and DEPT¹³C NMR. Finally, the animicrobile activity of these compounds were evaluated by the well diffusion assay against S. aureus Gram-positive and E. coli Gram-negative bacteria.

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