Synthesis and Characterization of a New Series of [1, 3]-Oxazepine  Compounds from Heterocyclic Schiff Bases

Roshna B. Nadr; Bana S. Abdulrahman

doi:10.21271/ZJPAS.35.2.21

Authors

Roshna B. Nadr Department of Chemistry, Faculty of Science and Health, Koya University, Koya KOY45, Kurdistan Region - F.R. Iraq
Bana S. Abdulrahman Department of Chemistry, Faculty of Science and Health, Koya University, Koya KOY45, Kurdistan Region - F.R. Iraq

DOI:

https://doi.org/10.21271/ZJPAS.35.2.21

Keywords:

Heterocyclic Schiff bases, new serious [1, 3]-Oxazepine

Abstract

In this study a new Series of aromatic heterocyclic [1, 3]-oxazepine have been synthesized by two steps. The first-step included synthesis of imine derivatives (1–7) using glacial acetic acid as a catalyst in the condensation reaction of 4-(6-methylbenzothiazol-2-yl)aniline with various substituted aromatic aldehydes. While in a second step, a series of seven-membered heterocyclic ring derivatives (8-14) obtained from Schiff base derivatives with phathalic anhydride in dry benzene. A variety of experimental techniques were used to characterize the new derivatives, including melting point, FT-IR, ¹H-NMR, and ¹³C-NMR. Finally, the synthesized compounds were screened against two types of bacteria both Staphylococcus aureus Gram (+ve) and Escherichia coli Gram (-ve) microorganisms. The results revealed that slightly active to good active against both types of test organisms of bacteria.

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