Antioxidants, Anti-inflammation, Anti-hyperglycemia and Chemical  Evaluation of the whole plant extracts of Anisopus mannii N.E.Br.

Muhammad Usman; Mahmoud Dogara Abdulrahman; Saber Hamad; Harmand A. Hama; Abubakar Abdullahi Lema

doi:10.21271/ZJPAS.34.5.10

Authors

Muhammad Usman National Board for Arabic and Islamic Studies, Kaduna, Nigeria
Mahmoud Dogara Abdulrahman Department of Biology, Faculty of Education, Tishk International University, Erbil Iraq
Saber Hamad Department of Biology, Faculty of Education, Tishk International University-Erbil, Kurdistan Region, Iraq
Harmand A. Hama Department of Biology, Faculty of Education, Tishk International University-Erbil, Kurdistan Region, Iraq
Abubakar Abdullahi Lema Department of Plant Science and Biotechnology, Faculty of Bioresources and Food Industry, Universiti Sultan Zainal Abidin (UniSZA), Besut Campus, 22200, Terengganu, Malaysia

DOI:

https://doi.org/10.21271/ZJPAS.34.5.10

Keywords:

Africa, Antioxidant, Medicinal plants.

Abstract

Anisopus mannii from the family Asclepiadaceae is a perennial herb that is currently utilized in the traditional Northern Nigerian medicinal system. The study document comprehensive In Vitro biological evaluation and chemical profiling of A. mannii whole plant crude extracts. Qualitative phytochemical, antioxidants, anti-inflammation, anti-hyperglycemia and chemical profiling was determined. The results revealed the presence of phenols, alkaloids, tannins, glycosides flavonoids, and saponins. The plant has the inhibition capacity to convert Fe³⁺ to Fe²at 18.9 mmol/gm, scavenging at 75.5, injured tissues 28.4 75.5, -amylase 62.7 and α-Glucosidase 89.5 µg /mL respectively. 9-Octadecenoic acid, methyl and Lup-20(29)-en-3-ol, acetate, (3. beta) are the major compounds found in the whole plant extract. The current groundbreaking research revealed ethanolic extract from the whole plant is an effective medicinal agent. It provides the possibility for different therapy regimens to be developed from it. Research is needed to discover and purify the active chemicals that are responsible for therapeutic efficacy.

References

Abdulrahman MD, Zakariya AM, Hama H. A., Hamad, S. W., Al-Rawi, S. S., Bradosty, S. W and Ibrahim AH. (2022). Ethnopharmacology, Biological Evaluation, and Chemical Composition of Ziziphus spina-christi (L.) Desf.: A Review. Advances in Pharmacological and Pharmaceutical Sciences, 2022. https://doi.org/10.1155/2022/4495688.

Abdulrahman, MD, Ali AM, Fatihah H, Khandaker MM and Mat N (2018). Traditional medicinal knowledge of Malays in Terengganu, Peninsular Malaysia. Malayan Nature Journal., 70(3): 349-364.

Abdulrahman M (2021). Antioxidant, alpha glucosidase and antibacterial evaluation of Syzygium mytifolium (Roxb.) Walp. Plant Sci. Today., 8 (2): 410-415.

Abdulrahman M. 2021. Ethnobotany of Medicinal Plants with Antidiabetic Potentials in Northern Nigeria. Eurasian j. sci. eng, 7: 46-58.

Abdulrahman MD, Ali AM, Moneruzzaman M (2019). Review on traditional knowledge and utilisation of medicinal plants. Biosci. Res., 16 (2): 3298-3313.

Abdulrahman MD, Hasan Nudin N, Khandaker MM, Ali AM and Mat N (2019). In vitro biological investigations on Syzygium polyanthum cultivars. Int J Agric Biol., 22: 1399-1406.

Aladeniyi I, Adeniyi OV, Fawole O, Adeolu M, Ter Goon D, Ajayi AI, Iruedo J (2017). The prevalence and correlates of pre-diabetes and diabetes mellitus among public category workers in Akure, Nigeria. The Open Public Health J., 10: 114-124.

Aliyu A, Ibrahim H, Musa A, Ibrahim M, Oyewale A and Amupitan, J. (2010). In vitro evaluation of antioxidant activity of Anisopus mannii NE Br. Afr. J. Biotechnol., 9(16): 2437-2441.

Djeridane A, Yousfi, M, Nadjemi B, Vidal N, Lesgards J and Stocker P (2007). Screening of some Algerian medicinal plants for the phenolic compounds and their antioxidant activity. Eur Food Res Technol., 224: 801-809.

Dogara A, Labaran I, Hamad SW, Lema AA, Jakada BH. 2021. Traditional Medicinal plants Used for the Treatment of Cancer in Mubi, Adamawa State, Nigeria. Al-Qadisiyah Journal of Pure Science, 26: 258-268.

Dogara AM (2022). Review of Ethnopharmacology, Morpho-Anatomy, Biological Evaluation and Chemical Composition of Syzygium polyanthum (Wight) Walp. Plant Sc. Today., 9(1): 167–177.

Escriche I, Juan BM (2018). Standardizing the analysis of phenolic profile in propolis. Food Res. Int., 106: 834-841.

Gavamukulya Y, Abou EF, Wamunyokoli F and El-Shemy HA. 2015. GC-MS analysis of bioactive phytochemicals present in ethanolic extracts of leaves of Annona muricata: A further evidence for its medicinal diversity. Pharmacogn. J., 7(5): 300-3004.

Gilani AH (2005). Trends in ethnopharmacology. J. Ethnopharmacol., 100 (1-2): 43-49.

Gupta D, Dubey J and Kumar M (2016). Phytochemical analysis and antimicrobial activity of some medicinal plants against selected common human pathogenic microorganisms. Asian Pac. J. Trop. Dis., 6(1): 15-20.

Hussain AI, Chatha SA, Noor S, Khan ZA, Arshad MU, Rathore HA and Sattar MZ (2012). Effect of extraction techniques and solvent systems on the extraction of antioxidant components from peanut (Arachis hypogaea L.) hulls. Food Anal. Methods., 5: 890-896.

Kazeem M, Adamson J and Ogunwande I (2013). Modes of inhibition of α-amylase and α-glucosidase by aqueous extract of Morinda lucida Benth leaf. BioMed research international., https://doi.org/10.1155/2013/527570.

Konaté K, Yomalan K, Sytar O, Zerbo P, Brestic, M, Patrick VD and Barro N (2014). Free radicals scavenging capacity, antidiabetic and antihypertensive activities of flavonoid-rich fractions from leaves of Trichilia emetica and Opilia amentacea in an animal model of type 2 diabetes mellitus. J Evid Based Complementary Altern Med., https://doi.org/10.1155/2014/867075.

Kunwar RM, Uprety Y, Burlakoti C, Chowdhary C and Bussmann RW (2009). Indigenous use and ethnopharmacology of medicinal plants in far-west Nepal. Ethnobot. Res. Appl., 7: 005-028.

Mahmoud AD and Abba A (2021). Ethnomedicinal Survey of Plants used for Management of Inflammatory Diseases in Ringim Local Government, Jigawa State, Nigeria. Ethnobot. Res. Appl., 22: 1-27.

Musa AM, Ibrahim MA, Aliyu AB, Abdullahi MS, Tajuddeen N, Ibrahim H and Oyewale AO (2015). Chemical composition and antimicrobial activity of hexane leaf extract of Anisopus mannii (Asclepiadaceae). J. Intercult. Ethnopharmacol., 4(2): 129-136.

Omoruyi BE, Bradley G and Afolayan AJ (2012). Antioxidant and phytochemical properties of Carpobrotus edulis (L.) bolus leaf used for the management of common infections in HIV/AIDS patients in Eastern Cape Province. BMC Complement Altern. Med., 12: 1-9.

Ramli S, Radu S, Shaari K and Rukayadi Y (2017). Antibacterial activity of ethanolic extract of Syzygium polyanthum L.(Salam) leaves against foodborne pathogens and application as food sanitizer. Biomed Res. Int., https://www.hindawi.com/journals/bmri/2017/9024246/.

Ruiz NY, Viuda MM, Sendra E, Perez AJ and Fernández LJ (2013). In vitro antibacterial and antioxidant properties of chitosan edible films incorporated with Thymus moroderi or Thymus piperella essential oils. Food Control., 30: 386-392.

Sermakkani M, Thangapandian V (2012). GC-MS analysis of Cassia italica leaf methanol extract. Asian J Pharm Clin Res., 5: 90-94.

Shibula K, Velavan S (2015). Determination of phytocomponents in methanolic extract of Annona muricata leaf using GC-MS technique. Int. J. Pharmacogn., 7 (6): 1251-1255.

Singh B, Nadkarni JR, Vishwakarma RA, Bharate SB, Nivsarkar M andAnandjiwala S (2012). The hydroalcoholic extract of Cassia alata (Linn.) leaves and its major compound rhein exhibits antiallergic activity via mast cell stabilization and lipoxygenase inhibition. J. Ethnopharmacol., 141: 469-473.

Stojkovic D, Smiljkovic M, Ciric A, Glamoclija J, Van GL, Ferreira IC, Sokovic M. 2019. An insight into antidiabetic properties of six medicinal and edible mushrooms: Inhibition of α-amylase and α-glucosidase linked to type-2 diabetes. S. Afr. J. Bot, 120: 100-103.

Tundis R, Loizzo M, Menichini F (2010). Natural products as α-amylase and α-glucosidase inhibitors and their hypoglycaemic potential in the treatment of diabetes: an update. Mini Rev Med Chem., 10 (4): 315-331.

Yadav R, Agarwala M (2011). Phytochemical analysis of some medicinal plants. Journal of phytology, 3(12):10-14.