Association of kisspeptin with thyroid hormone levels in patients with hyperthyroidism in Erbil city

Awat Y.Hasan; Chiman M.Jawdat; Ahmed H.Ahmed; Ismail M. Maulood; Almas M.R Mahmud

doi:10.21271/ZJPAS.35.6.14

Authors

Awat Y.Hasan Department of Biology, College of Science, SalahaddinUniversity-Erbil, Kurdistan Region, Iraq
Chiman M.Jawdat Biology Department, Faculty of Science,Soran University,Kurdistan Region ,Iraq
Ahmed H.Ahmed Department of Biology, College of Science, SalahaddinUniversity-Erbil, Kurdistan Region, Iraq
Ismail M. Maulood Department of Biology, College of Science, SalahaddinUniversity-Erbil, Kurdistan Region, Iraq
Almas M.R Mahmud Department of Biology, College of Science, SalahaddinUniversity-Erbil, Kurdistan Region, Iraq

DOI:

https://doi.org/10.21271/ZJPAS.35.6.14

Keywords:

Hyperthyroidism, Kisspeptin, Thyroxin, SBP, DBP, BMI

Abstract

Background: Hyperthyroidism is a pathological disorder in which excess thyroid hormone is synthesized and secreted by the thyroid gland. There is a few studies ndicate a correlation between the levels of T4 and blood pressure with Kisspeptin hormone levels ,therefore the present study is focusing on the evaluation of kisspeptin in hyperthyroid patients and its association with systolic blood pressure (SBP), diastolic blood pressure (DBP), heart rate, and body mass index (BMI)

. Materials and methods: The study included 80 participants from both sexes who were divided into two groups Group 1 Including healthy subjects and Group 2 Including 40 hyperthyroid subjects. Results: The results showed significant differences in the concentration of the T4 and kissiptin hormones between control and patients with hyperthyroidism On the other hand, concentration of Kisspeptin significantly and negatively correlated with DBP .While negative non-significant correlation existed between , SBP, MAP level and kisspeptin concentration . The cut-off value for Kisspeptin was found to be >20.2 with good sensitivity and specificity, indicating its potential use as a diagnostic marker for hyperthyroidism in females. Conclusions: These findings highlight the potential role of kisspeptin as a diagnostic marker for hyperthyroidism, particularly in female patients

References

ANDREOZZI, F., MANNINO, G. C., MANCUSO, E., SPIGA, R., PERTICONE, F. & SESTI, G. 2017. Plasma kisspeptin levels are associated with insulin secretion in nondiabetic individuals. PLoS One, 12, e0179834.

BILBAN, M., GHAFFARI-TABRIZI, N., HINTERMANN, E., BAUER, S., MOLZER, S., ZORATTI, C., MALLI, R., SHARABI, A., HIDEN, U. & GRAIER, W. 2004. Kisspeptin-10, a KiSS-1/metastin-derived decapeptide, is a physiological invasion inhibitor of primary human trophoblasts. Journal of cell science, 117, 1319-1328.

BORON, W. F. & BOULPAEP, E. L. 2012. Medical physiology, 2e updated edition e-book: with student consult online access, Elsevier health sciences.

CARLSTRÖM, M. 2021. Nitric oxide signalling in kidney regulation and cardiometabolic health. Nat Rev Nephrol, 17, 575-590.

CHO, S. G., LI, D., STAFFORD, L. J., LUO, J., RODRIGUEZ‐VILLANUEVA, M., WANG, Y. & LIU, M. 2009. KiSS1 suppresses TNFα‐induced breast cancer cell invasion via an inhibition of RhoA‐Mediated NF‐κB activation. Journal of cellular biochemistry, 107, 1139-1149.

D'ANGLEMONT DE TASSIGNY, X. & COLLEDGE, W. H. 2010. The role of kisspeptin signaling in reproduction. Physiology, 25, 207-217.

DUNGAN, H. M., CLIFTON, D. K. & STEINER, R. A. 2006. Minireview: kisspeptin neurons as central processors in the regulation of gonadotropin-releasing hormone secretion. Endocrinology, 147, 1154-1158.

HAN, X., YAN, M., AN, X. F., HE, M. & YU, J. Y. 2010. Central administration of kisspeptin-10 inhibits natriuresis and diuresis induced by blood volume expansion in anesthetized male rats. Acta Pharmacol Sin, 31, 145-9.

JAYASENA, C. N., ABBARA, A., COMNINOS, A. N., NIJHER, G. M., CHRISTOPOULOS, G., NARAYANASWAMY, S., IZZI-ENGBEAYA, C., SRIDHARAN, M., MASON, A. J., WARWICK, J., ASHBY, D., GHATEI, M. A., BLOOM, S. R., CARBY, A., TREW, G. H. & DHILLO, W. S. 2014. Kisspeptin-54 triggers egg maturation in women undergoing in vitro fertilization. J Clin Invest, 124, 3667-77.

JAYASENA, C. N., NIJHER, G. M., COMNINOS, A. N., ABBARA, A., JANUSZEWKI, A., VAAL, M. L., SRISKANDARAJAH, L., MURPHY, K. G., FARZAD, Z., GHATEI, M. A., BLOOM, S. R. & DHILLO, W. S. 2011. The effects of kisspeptin-10 on reproductive hormone release show sexual dimorphism in humans. J Clin Endocrinol Metab, 96, E1963-72.

LATIF, R. & RAFIQUE, N. 2015. Serum kisspeptin levels across different phases of the menstrual cycle and their correlation with serum oestradiol. Neth J Med, 73, 175-8.

LOGIE, J. J., DENISON, F. C., RILEY, S. C., RAMAESH, T., FORBES, S., NORMAN, J. E. & REYNOLDS, R. M. 2012. Evaluation of kisspeptin levels in obese pregnancy as a biomarker for pre-eclampsia. Clin Endocrinol (Oxf), 76, 887-93.

MANOUSAKI, D. & VAN VLIET, G. 2022. Population-based TSH screening of newborns for hyperthyroidism: it may be feasible, but is it justified? The Journal of Clinical Endocrinology & Metabolism, 107, e2630-e2631.

NIJHER, G. M., CHAUDHRI, O. B., RAMACHANDRAN, R., MURPHY, K. G., ZAC-VARGHESE, S. E., FOWLER, A., CHINTHAPALLI, K., PATTERSON, M., THOMPSON, E. L., WILLIAMSON, C., KUMAR, S., GHATEI, M. A., BLOOM, S. R. & DHILLO, W. S. 2010. The effects of kisspeptin-54 on blood pressure in humans and plasma kisspeptin concentrations in hypertensive diseases of pregnancy. Br J Clin Pharmacol, 70, 674-81.

NOVAIRA, H. J., NG, Y., WOLFE, A. & RADOVICK, S. 2009. Kisspeptin increases GnRH mRNA expression and secretion in GnRH secreting neuronal cell lines. Mol Cell Endocrinol, 311, 126-34.

NÚÑEZ, A., BEDREGAL, P., BECERRA, C. & GROB, L. F. 2017. [Neurodevelopmental assessment of patients with congenital hypothyroidism]. Rev Med Chil, 145, 1579-1587.

OGAWA, S., NG, K. W., XUE, X., RAMADASAN, P. N., SIVALINGAM, M., LI, S., LEVAVI-SIVAN, B., LIN, H., LIU, X. & PARHAR, I. S. 2013. Thyroid Hormone Upregulates Hypothalamic kiss2 Gene in the Male Nile Tilapia, Oreochromis niloticus. Frontiers in endocrinology, 4, 184-184.

PANIDIS, D., ROUSSO, D., KOLIAKOS, G., KOURTIS, A., KATSIKIS, I., FARMAKIOTIS, D., VOTSI, E. & DIAMANTI-KANDARAKIS, E. 2006. Plasma metastin levels are negatively correlated with insulin resistance and free androgens in women with polycystic ovary syndrome. Fertility and sterility, 85, 1778-1783.

SAWYER, I., SMILLIE, S.-J., BODKIN, J. V., FERNANDES, E., O'BYRNE, K. T. & BRAIN, S. D. 2011. The Vasoactive Potential of Kisspeptin-10 in the Peripheral Vasculature. PLOS ONE, 6, e14671.

SCHWEIZER, U. & KÖHRLE, J. 2013. Function of thyroid hormone transporters in the central nervous system. Biochim Biophys Acta, 1830, 3965-73.

SUN, J., HUI, C., XIA, T., XU, M., DENG, D., PAN, F. & WANG, Y. 2018. Effect of hypothyroidism on the hypothalamic-pituitary-ovarian axis and reproductive function of pregnant rats. BMC Endocr Disord, 18, 30.

TEN, S. C., GU, S. Y., NIU, Y. F., AN, X. F., YAN, M. & HE, M. 2010. Central administration of kisspeptin-10 inhibits water and sodium excretion of anesthetized male rats and the involvement of arginine vasopressin. Endocr Res, 35, 128-36.

TOLSON, K. P., GARCIA, C., DELGADO, I., MAROOKI, N. & KAUFFMAN, A. S. 2016. Metabolism and energy expenditure, but not feeding or glucose tolerance, are impaired in young Kiss1r KO female mice. Endocrinology, 157, 4192-4199.

WEN, L., LIN, W., LI, Q., CHEN, G. & WEN, J. 2020. Effect of sleeve gastrectomy on kisspeptin expression in the hypothalamus of rats with polycystic ovary syndrome. Obesity, 28, 1117-1128.

ZHOU, Q., CHEN, H., YANG, S., LI, Y., WANG, B., CHEN, Y. & WU, X. 2014. High-fat diet decreases the expression of Kiss1 mRNA and kisspeptin in the ovary, and increases ovulatory dysfunction in postpubertal female rats. Reprod Biol Endocrinol, 12, 127.